Revance won approval based on data from the Phase III ASPEN 1 and ASPEN OLS trials in which Daxxify was found to be safe and effective at two separate injected doses with a median duration of effect of 24 and 20.3 weeks for the respective groups
It plays an important role in the metabolism of fatty acids, pyrimidines, and lysosomes and mediates the expression of several genes, including those involved in inflammation [128]
Anti-inflammatory cytokines include Th2 type cytokines (IL-4, IL-5, IL-10)
Diabetes Care 44(1):224230
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