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That role falls principally to generic drugs, and to policies that ensure there is brisk competition once legitimate intellectual property protections have lapsed

However, leakage of electrons in this process results in the formation of superoxide anion radicals, namely, mROS ( via tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) and evolutionarily conserved signaling intermediate in toll pathways (ECSIT), leading to the phagocytosis of mitochondria and eventually contributing to mROS production ( Notably, mROS is constitutively produced from OXPHOS at the physiological status that supports many signaling pathways and maintains the normal machinery of the innate immune system

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Despite their promise, a significant challenge in the development, formulation, and manufacturing of these therapeutics lies in the formation of complex molecular structuresranging from oligomers to aggregates and fibrils