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10.1038/ncb1552 165 JeonG

Studies (105, 106) have found that GE also has a role in preventing angiogenesis in RA, which is related to the up-regulation of the expression of phosphate and tension homelessness deleted on chromoten (PTEN) to inhibit PI3K/Akt signal activation, the restoration of dynamic balance of pro/anti-angiogenic factors in vascular endothelial cells (VEC), and the reduction of FLSs stimulation to VEC by inhibiting the VEGF/SPK1/S1P pathway

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For example, a severe case of urine color and liver disease can cause the liver to produce excess bilirubin, a pigment that is normally broken down and excreted

Both neurogenic inflammation and oxidative stress are key factors in migraine development, and topiramates neuroprotective potential through its anti-inflammatory and antioxidative effects is noted