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In the CNS, iron is accumulated mainly by astrocytes and to a somewhat lesser extent by microglia

Other indirect evidence also comes from the coordinated response of enzyme activities and corresponding gene expression that is often observed in response to stress

Moderate physical activity improves insulin sensitivity, promotes circulation, and contributes to weight regulation

Fibroblasts secrete inflammatory cytokines and chemokines, such as tumor necrosis factor-alpha (TNF-), IL-1, and chemokine (C-X-C Motif) ligand 8 (CXCL8), contributing to the inflammatory environment

The mechanisms are different enough that interactions are unpredictable