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For instance, ICA has an oral bioavailability of approximately 12% (F_rel 12%), primarily constrained by poor intestinal membrane permeability and extensive first-pass hepatic metabolism ( in vivo exposurewith Maximum plasma concentration (C_max) and Area under the plasma concentrationtime curve (AUC) values 3.8- and 13-fold higher than the parent metabolite, respectively ( Although these enhancements show promise, the translation into human studies remains limited