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Patients should undergo an appropriate medical assessment before starting treatment to ensure the medication is safe and suitable for their individual circumstances

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12,16 Transcriptional co-activators utilize acetyl CoA as cofactor and catalyse the transfer of an acetyl group to the -amino group of lysine side chains, 93 thereby neutralizing the positive charge of lysine that weakens the non-covalent electrostatic interactions between histones and negatively charged phosphate groups of DNA