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J Neurochem 75 : 16081617

Several important safety considerations from UK SmPCs include: Pancreatitis risk : Seek immediate medical attention for severe, persistent abdominal pain Gallbladder disease : Including cholelithiasis and cholecystitis Diabetic retinopathy complications : Particularly with semaglutide in those with pre-existing retinopathy Dehydration and acute kidney injury : Possible with severe gastrointestinal side effects Hypoglycaemia : Increased risk when used with insulin or sulfonylureas (dose adjustment of these medications may be needed) Pregnancy/breastfeeding : Weight management GLP-1 agonists (Wegovy, Saxenda) are contraindicated in pregnancy and should be avoided during breastfeeding [5] [2] Regarding mental health specifically, regulatory agencies have scrutinised GLP-1 medications for potential psychiatric adverse effects

However, as your body gets used to the increase of this amino acid in your body, or if you exceed the recommended dose, you may suffer from indigestion or heartburn

Benign melanocytic nevi are formed by nests of melanocytes at the epidermal junction (junctional nevi), in the dermis (intradermal nevi), or in both compartments (compound nevi)

Carlson ED, Gan R, Hodgman CE, Jewett MC