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Most of the catalases contain heme and catalase causes the dismutation of H 2 O 2 (a chemical reaction in which H 2 O 2 causes oxidation of the other H 2 O 2 molecules, consequently, one is converted to O 2 and the other two are converted to tow molecules of H 2 O) [54]

In addition, the observed side-chain flexibility of V12 and F112 indicated that these residues are mainly involved in the overall shaping of the active site and help to position the flavonoid substrate in accordance with the presented structural evidence

Initially, GLP-1 agonists were explored as a treatment for type 2 diabetes

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