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Acknowledgments We thank Drs

In this comprehensive article well explore what FOXO4-DRI is, how it works, the current pre-clinical evidence, its promise and limitations, comparisons with other senolytic approaches, safety and regulatory considerations, and what the future might hold for integrating this novel peptide into a clinical strategy for healthier ageing

In case of autoimmune components, auto-antibodies directed at fetal brain proteins might cause BBB damage (Zimmerman et al., 2007)

This effect occurs through activation of the STAT3 signaling pathway, which increases IL-8 secretion by macrophages