There's no reason to think that if you treat hundreds of thousands of people, there wouldn't be a spectrum of responses. Based on the available evidence, though, Drucker emphasized it would be an extremely rare side effect
PATHOPHYSIOLOGY AND PHARMACOLOGY OF T2DM People with T2DM present with a variety of core organ defects that contribute to hyperglycemia
These inputs are used to enhance local release within a defined time window and, in some designs, to introduce additional photothermal, photodynamic or sonodynamic effects that act in concert with the delivered drug [50, 52]
52 For example, during ischemic injury, the heart experiences an overload of misfolded proteins due to oxidative stress and energy depletion

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