I would err on the side of caution. Despite questions over the evidence base, marketing frequently boasts of impressive results, with double chins, bingo wings and muffin tops seemingly eradicated in a few sessions
Specifically, ANO6 upregulates ChaC1, associated with ferroptosis, by increasing intracellular iron and ROS levels, promoting lipid peroxidation and cell death
For a fuller discussion of the asymptomatic gallstone question, see our dedicated page on asymptomatic gallstones
December 15, 2025: Ozempic Blindness MDL Is Created for Patients Who Suffered Eye Stroke After Taking GLP-1s Patients diagnosed with non-arteritic anterior ischemic optic neuropathy (NAION) after taking Ozempic, other GLP-1s, can file a lawsuit in the new MDL created for these cases
Outcomes remain highly uncertain and hinge on uptake, effectiveness, persistency, and any benefits beyond BMI reduction so insurers should monitor this fast-moving landscape and consider implications for trend assumptions, lapse/anti-selection risk, underwriting, and claims
