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Lipomatous lesions of unknown cellular origin in the liver of B6C3F1 mice

Among those tested, Cur10 demonstrated the strongest binding, exhibiting the lowest IC 50 value of 9.64 M, while Cur07 and Cur06 showed IC 50 values of 19.86 M and 20.79 M, respectively (467)

Holland, S., et al

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Surprisingly, mice with specific genetic deletion of Gpx1 appear phenotypically normal and with normal life span (Ho et al., 1997), suggesting that there are alternative compensatory mechanisms for H 2 O 2 scavenging in Gpx1 deficiency