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Another team reported that 9 patients taking semaglutide and tirzepatide (the active ingredient in Zepbound and Mounjaro) experienced side effects in their eyes, including NAION and two other eye conditions that could lead to vision loss

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Interestingly, the aryl hydrocarbon receptor (AhR) of the tryptophan-kynurenine pathway serves as a critically important mediator between tryptophan metabolism, immune reactions, and tissue homeostasis (4143), and several kynurenine metabolites have been associated with fatigue (44, 45)

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