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It is worth noting that when glutamine is depleted, upregulated amino acid transporters, such as SLC1A3 (aspartic acid/glutamate transporter) and SLC7A3 (arginine transporter) were observed

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Acknowledgements The authors would like to sincerely thank the following individuals and institutions who made vital contributions to this study: We thank Rhyad Al-issa from the Department of Biochemistry, College of Medicine, King Khalid University, for his technical support in the preparation of the electron microscopic slides