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The Role of Vitamin C Vitamin C is perhaps the most important "partner" for glutathione

Recent studies demonstrated that individuals with glutathione transferase omega polymorphisms, genotype variants GSTO1*AA (rs4925) and GSTO2*GG (rs156697), showed significant propensity towards development of clinical manifestations in COVID-19 supporting the significance of these enzymes in the regulation of redox homeostasis and immune response, especially NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation (Zhao and Zhao, 2020

systematically reviewed the oxidative stress from the perspectives of oxidants and antioxidants, and noted that oxidants with vastly different half-lives may be observed at the site of generation or be transported to distant target sites where they exert oxidant activities in cell metabolism [63]

Nat Rev Drug Discov

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