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This type of direct interaction within well-defined physical boundaries, such as axons and their synapses, represents a discrete type of transmission known as wired transmission

S2CID 251658492

doi: 10.1073/pnas.84.24.8879

Taken together, these observations suggest that except in vitamin B 12 deficiency (which only responds to cyanocobalamin treatment because of the inactivation of methionine synthase), folate treatment should be the most adequate therapy to reverse hyperhomocysteinemia detected both under basal conditions and after an oral methionine load

both groups can find a meaningful middle ground when the menus are coherent and the categories are descriptive