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Tirzepatide's dual action on two hormone pathways may offer an additive effect, potentially leading to more significant weight loss than semaglutide

doi: 10.2337/diacare.17.2.142

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In animal models, GLP-1 receptor agonists reduce cocaine, methamphetamine/amphetamine, and nicotine-related behaviors, including drug taking, motivation to use, and relapse-like seeking