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139 Liraglutide also rescued the deleterious effects of a high-fat diet on hippocampal LTP of neurotransmission 140 and enhanced the number of hippocampal and cortical synapses in AD model mice

To clarify whether elevated AMPK and SIRT6 expression following GLP-1RA treatment influenced SREBP-2 expression, HepG2 cells were pre-transfected with AMPK or SIRT6 siRNA for 24 hours, followed by PA and GLP-1RA treatments

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