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We thank the laboratory assistance from Yu-Ting Yang, Ying-Tzu Li, Chang-Hao Lai, and Pei-Lin Wang

MC1R is expressed on keratinocytes, fibroblasts, dendritic cells, mast cells, and other immune cells in the skin , and MT-1-mediated MC1R activation produces anti-inflammatory effects in these cell types through cAMP-mediated suppression of NF-B activation, reduction of pro-inflammatory cytokine production including TNF-alpha and IL-6, inhibition of reactive oxygen species generation, and modulation of dendritic cell maturation and antigen presentation

Seizures have been associated with L-carnitine use in those with and without seizure disorders

The odds of severe COVID-19 outcomes increase by 38.1 and 5.6 times for vit-D-deficiency and -insufficiency patients, respectively, for each standard deviation decrease in serum 25(OH)D 694

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