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Ligand-receptor interactions were analysed by using Cellchat 94

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Upon its accumulation and phosphorylation, HIF-1 dimerizes with HIF- (constitutively expressed nuclear proteins), enters the nucleus, and promotes the transcription of hypoxia response elements (HRE)-containing target genes involved in energy metabolism, erythropoiesis, vascular remodelling, and other processes (Fig

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Lemon Bottle treatment typically requires 2-5 sessions spaced 1-2 weeks apart, depending on the treatment area and the amount of localised fat