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Liu X, Li J, Guo C, Wang H, Sun Y, Wang H, et al

Simultaneously, LPS significantly inhibits the expression of hepatic SIRT1 and FOXA2, which downregulates the NFE2L2/HMOX1 antioxidant signaling axis, diminishes the activity of key antioxidant enzymes (e.g., CAT, SOD, and GPX1), and upregulates autophagy-related proteins such as MAP1LC3-II and ATG5 171

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