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The other receptor that Dihexa binds to is c-MET, also known as the hepatocyte growth factor (HGF) receptor

Moreover, this metabolic shift from glycolysis to FAO in senescent ECs is closely associated with increased secretion of proinflammatory factors characteristic of the senescence-associated secretory phenotype (SASP), which exacerbates chronic vascular inflammation (often referred to as inflammaging) and contributes to vascular diseases such as atherosclerosis and hypertension [105]

Heavy pollution exposure, smoking, poor sleep and a diet low in protein variety are useful clues in the meantime

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