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Think of it as cellular housekeeping that keeps things running cleanly 16

Systemic inflammatory response syndrome (SIRS) following unregulated IV administration, presenting with fever above 41 degrees Celsius, acute liver injury, and clotting abnormalities, is also documented in a 2025 case report

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These associations remained consistent across subgroup analyses, including patients using tirzepatide as adjunctive therapy to other first-line diabetes agents, among patients older than 60 and comparisons against individual GLP-1 drugs, including semaglutide and dulaglutide