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6 Evidence Strength Assessment NAC has a broader and more extensively replicated human evidence base, including two published meta-analyses and RCTs across diverse clinical populations

Data limitations: No completed human efficacy trial exists for any indication, and the literatures short observation windows mean long-term safety in either animals or humans remains unestablished

The potential for long-term KLOW side effects is still an open question that only meticulous, longitudinal research can answer

Clients with underlying medical issues and/or a history of poor health, diabetes, thyroid conditions, endocrine conditions, or any other health-related conditions that may contribute to weight gain or a compromised metabolism may not respond to the proposed treatment and/or may require additional treatment sessions.

These limitations hinder the reliability and applicability of pooled effect estimates and make it difficult to issue strong clinical recommendations for or against TCM use of TCM for tinnitus