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In addition, the recovery of E GSH [IMS] after oxidant treatment is strongly impaired in glr1 cells compared to wt cells (Figure 3C)

[19] There are several GLP-1 receptor agonists approved in the EU to treat diabetes and weight management

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Astrogliosis is prevalent in the epilepsies, and interestingly a mouse forebrain neuron-specific knockout of SOD2 resulted in seizures, oxidative stress, and marked GFAP and vimentin gene upregulation, indicative of astrogliosis resulting from increased neuronal mtROS (Fulton et al., 2021)