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4 Although these findings are promising, randomized clinical trials are needed to clarify the potential efficacy of GLP-1 RAs for AUD and SUD treatment

Several studies have reported that inhibition of the Proteasome may play a causal role in the neurotoxicity associated with oxidative stress, under conditions that may even be sufficient to induce neural death [15]

Poly (ADP-ribose) polymerase-1 (PARP-1) is an enzyme involved in both DNA repair and transcriptional regulation