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Regarding gene expression, SOD3 mRNA expression was found to be upregulated in patients with advanced MASLD as compared to those with mild MASLD

Protective effect of total flavonoids of Engelhardia roxburghiana Wall

Nov 2015;1852(11):2442-2455

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Notably, all patients had previously been treated with pentosan polysulfate, which is currently the only FDA approved treatment for interstitial cystitis, and had not responded