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Once the therapeutic effect begun, the therapeutic effect is continuous, and neither of the continuous ligation-induced disturbances reappeared (Vukojevic et al., 2018
10.1111/joim.12382 J Intern Med
Additionally, castration considerably decreased the expression of important antioxidant enzymes (AOEs) (GPx1, thioredoxin, SOD2, and peroxiredoxin 5) and markedly increased the expression of ROS-generating NAD(P)H oxidases
The catalytic glutamate residue E 115 accepts a proton from the -glutamyl group of the substrate, initiating a nucleophilic attack by the amine on the amide carbon atom
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