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This has led to a surge of interest in various methods of boosting it, including dietary changes, supplements, and yes, even coffee enemas

doi: 10.1016/j.bcp.2018.06.003 110 ShubinaVSKozinaVIShatalinYV

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The landmark FLOW trial , published in the New England Journal of Medicine in 2024, demonstrated that semaglutide reduced the risk of major kidney disease events by 24% in patients with type 2 diabetes and chronic kidney disease (hazard ratio 0.76