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A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient
BMJ (Online) 349
If you do not intend to use the entire vial within this timeframe, divide the reconstituted solution into smaller, single-use aliquots and freeze them at -20C
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