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Animal studies have demonstrated that GLP-1 receptor agonists can decrease self-administration of alcohol, cocaine, nicotine, and opioids in rodent models, though these findings require translation to human clinical outcomes

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The study also found that retatrutides effects on weight loss had not plateaued by the end of the 48-week period, suggesting potential for even greater weight reduction with longer treatment duration

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Many patients focus solely on weight loss, but I emphasize metabolic markers equally