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This mechanism can: Delay or reduce absorption of oral drugs Increase variability in drug exposure Be amplified by nausea, vomiting, and diarrhoea Which means Not all oral medications behave as expected Contraception: a real-world safety signal This is where the issue becomes tangible

the borders are usually irregular The macules may be single or multiple The underlying skin or mucosal surface usually remains unaffected

Patients who receive a combination of anesthetic and steroid medication may notice a slight increase in pain after the injection as the numbing medicine wears off and the cortisone starts to take effect

(PubMed) Watkins D, Rosenblatt DS