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Compared with controls, adherent SC-islets treated with ZnPTO exhibited a higher proportion of EGFP + GCG + cells, supporting the hypothesis that excessive zinc induces the conversion of SC- cells into SC- cells (Supplementary information, Fig

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Other growth factors such as bone morphogenetic proteins (BMPs) have received FDA approval for specific indications and may represent more appropriate therapeutic choices for conditions where approved therapies are available and indicated