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Dimidi E, Christodoulides S, Fragkos KC, Scott SM, Whelan K

Another example involves esterase-degradable antimicrobial nanosponges, which are engineered by polymer-stabilizing self-assembled cationic poly(oxanorborneneimide) (PONI) scaffolds bearing guanidine, maleimide, and tetraethyleneglycol monomethyl ether (GMT) groups around essential-oil cores, followed by crosslinking with dithiol-disulfide (DTDS)

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In this study, dose-escalation of LY3437943 to 12 mg once weekly over a period of 12 weeks resulted in an additional body-weight loss of 9 kg compared with both the placebo and dulaglutide, while demonstrating an acceptable safety profile