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L., Silva, B

We show here that mitapivat, an oral PK activator, ameliorates anemia in 4.2 / mice, a model for human HS, by reprograming the RBC metabolome

Therapeutic effects become more noticeable

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In addition, GLP-1R can be continuously activated to activate cAMP and P38 (94) and inhibit the conduction of the AKT and ERK1/2 signaling pathways (14, 16), ultimately inhibiting the proliferation of transplanted tumors in vivo and inducing the apoptosis of human pancreatic cancer cells in vitro ( 14)