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Vomiting that prevents you from staying hydrated, severe abdominal pain, signs of dehydration, allergic reaction symptoms, or any of the red flag symptoms described earlier require prompt medical attention

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You should contact your GP if you: Develop sudden, severe joint pain , particularly if accompanied by swelling, warmth, and rednessthese are hallmark symptoms of an acute gout attack Have a history of gout and notice an increase in the frequency or severity of flares after starting Ozempic Experience symptoms of kidney stones , such as severe flank or abdominal pain, blood in the urine, or difficulty passing urine Are concerned about elevated uric acid levels identified in recent blood tests, especially if you have risk factors such as a family history of gout, chronic kidney disease, or are taking diuretics (which can raise uric acid levels) [15] Notice persistent nausea, vomiting, or diarrhoea while on Ozempic, as these may lead to dehydration and potentially affect uric acid levels Seek urgent medical attention if you experience severe joint pain with fever or systemic illness (which could indicate septic arthritis rather than gout) or if you are unable to pass urine with severe flank pain (which might suggest an obstructive kidney stone)

Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response