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7), effectively inhibiting neuropeptide release from NPY/AgRP neurons, which suppresses appetiteIn mHypoE-N41 cells, TGR5 activation enhances the phosphorylation of ROCK classic targets, including myosin light chain (MLC) and COFILIN

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Some patients experience mild jitteriness during dose escalation that resolves within days, while others report persistent low-grade worry or panic sensations