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Peptidoglycan recognition by the immune system is probably mediated by the nucleotide-binding oligomerization domain (NOD) with the consequent alteration of pro-inflammatory pathways such as NF-kB and MAP kinase [68]

Follow-up imaging at six to twelve weeks can help assess whether conservative management is working

For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines ( Where relevant data were missing, attempts were made to contact corresponding authors

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