Disturbances in the intestinal endothelium, lymphoid atrophy, gut dysbiosis, and elevated inflammatory metabolites (TNF, specific pteridines, IL-1, IL-6 and IL-12, fecal calgranulin and myeloperoxidase) further compromise intestinal function [51, 106, 110,111,112] SAM-induced inflammation further inhibits micronutrient uptake, creating a downward spiral in SAM severity and increased morbidity and mortality [104, 113]
However, the effect of exercise intensity on metabolic alterations and circulating exerkine levels has not yet been systematically investigated
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Subtypes 1a and 1b are found worldwide and cause 60% of all cases
LPLA2 is a lysosome-associated enzyme central to lipid metabolism