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Ethics declarations Ethics approval and consent to participate All procedures used for this study were approved by University of Nebraska Medical Center Institutional Animal Care and Use Committee (IACUC, approval reference number: 14-036-07-FC) and conducted according to the National Institutes of Health guiding principles for the research involving animals

This article is the first to have drawn attention to the possible role of brain hypoxia in migraine pathogenesis

Results time varies from patient to patient and depends on many factors including: metabolism and overall health