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Thus, modulating FTH1 levels via upstream regulatory pathways may represent a key therapeutic strategy for HF

In some embodiments, the otoprotectant is a compound of Formula (XI): wherein: R 1 is C 6 -C 10 aryl or C 3 -C 9 heteroaryl, wherein C 6 -C 10 aryl and C 3 -C 9 heteroaryl are optionally substituted with one or more R 4

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Consequently, it is difficult to assess exactly how much GSH our bodies require as this amount can differ from person to person and can change from day to day

Macropinocytosis is an alternative pathway of cysteine acquisition and mitigates sorafenib-induced ferroptosis in hepatocellular carcinoma