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The ALDH2/SIRT3/HIF-1 axis plays a myocardial protective role, reducing 4-HNE levels post myocardial ischemia/reperfusion (I/R), resulting in decreased apoptosis, a reduced myocardial infarct size, and decreased ROS levels

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In particular, the C-terminal acidic residue in client proteins modulates coatomer subunit binding affinity, and hence selectivity

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90 mg: -2.50, p=0.0008)