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The usual intuition that a higher dose is at least a stronger version of the same thing is simply false here

If all your pens sat on the counter, the same 28-day cumulative clock applies to all of them

The OAD can result from mutations in genes encoding enzymes of fatty acid metabolism, enzymes of amino acid metabolism, and enzymes involved in several other metabolic pathways such as the TCA cycle

doi:10.1016/j.ceca.2012.02.008, PMID: 22480931 Jin M, Yaung J, Kannan R, He S, Ryan SJ, Hinton DR (2005) Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion

Additionally, ROS can react with unsaturated fatty acids on lipid membranes, leading to the production of free radicals and inducing fatty acid peroxidation, resulting in the generation of fatty acid-ROS (48)