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Shared epigenetic mechanisms in depression-drug addiction comorbidity To better integrate these findings, we introduce a unifying three-axis framework, stress-response regulation, reward-circuit remodeling, and synaptic plasticity, which provides a coherent structure for understanding how epigenetic alterations converge across depression, drug addiction, and drug addiction-induced depression

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The Particle Mesh Ewald (PME) method was used to treat all electrostatic interactions beyond a cutoff of 10 and the bonds involving hydrogen atoms were constrained using LINCS algorithm 60

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Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity