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Research from the STEP trial program shows that 1.0 mg is where the dose-response curve starts to steepen meaningfully

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Paradoxical Decreases in Heart Rate at Low Sub-Therapeutic Doses of Atropine (1) a central vagotonic mechanism , whereby low-dose atropine blocks inhibitory M1 muscarinic receptors in the central nervous system or parasympathetic ganglia, disinhibiting vagal outflow and increasing parasympathetic tone to the sinoatrial node (Kotona et al, 1977

When vascular damage occurs, local growth factors and cytokines signal the bone marrow to release EPC targeted to the injured sites

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