Biologic drugs target specific immune pathways, but patients may still suffer opportunistic infections and longterm risks like cancer
The primary enzymes involved in the nonoxidative steps of the PPP are transaldolase and transketolase
971 Lip@GluAC4A greatly decreases ferroptosis, enhances BBB permeability, and alleviates neurological dysfunction caused by rtPA therapy, all of which have important implications for the treatment and prognosis of patients with ischemic stroke
421,422,423,424,425 Future directions Future translational arterial stiffness research should (i) enhance clinical assessment (e.g., multimodal imaging, wearable-based PWV analysis in large clinical trials and population studies), (ii) identify specific phenotypes and endotypes, (iii) decipher the underlying mechanisms of the use of state-of-the-art technologies (e.g., specific microfluid cell culture systems, machine learning approaches) and new risk factors (e.g., chronic psychosocial stress, air pollution), and (iv) develop tailored prevention and therapeutic approaches (e.g., new pharmacological agents targeting low-grade systemic inflammation, AI-based personalized intervention)
It is common for patients to use several NSAIDs without proper knowledge of the consequences of such behavior and without medical consultation, which limits control over their safe use
