Usdin TB, Mezey E, Button DC, et al
Talk to your primary care doctor about your personal risk level
Long-term weight control usually depends on consistency, lifestyle choices, and a plan you can live with
Protocol 2: significant weight loss (20-25% body weight) Goal: Substantial weight reduction for health improvement Tirzepatide approach: Full escalation to 10-15 mg Expect to reach target dose by week 17-21 Weight loss at 15 mg: approximately 22.5% at 72 weeks Plateau typically occurs around weeks 60-72 Retatrutide approach: Full escalation to 8-12 mg Expect to reach target dose by week 13-17 Weight loss at 12 mg: 24.2% at 48 weeks, 28.7% at 68 weeks No plateau observed in trial data at 48 or 68 weeks For significant weight loss goals, retatrutide reaches 20%+ body weight reduction faster and ultimately achieves a higher ceiling
A provider may consider: IGF-1 Fasting glucose A1C Lipids Thyroid markers Liver and kidney markers Blood pressure Sleep quality Current medications Personal and family health history Lab review helps determine whether growth hormone support is appropriate, whether a safer alternative should be considered, and how treatment should be monitored over time
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