Biased vs Balanced Signaling# Weight Loss Data# Important caveat: The SLIMMER trial was conducted in a Chinese population only, which may have different body composition, baseline BMI distribution, and metabolic characteristics compared to the global populations studied in STEP trials
in The Biological Effects of Glutamic Acid and Its Derivatives (ed
The evidence, SELECT, n=17,604 First MACE: HR 0.80, 95% CI 0.72 to 0.90 Non-fatal MI: HR 0.72, 95% CI 0.61 to 0.85 Coronary revascularisation: HR 0.77, 95% CI 0.68 to 0.87 All-cause : HR 0.81, 95% CI 0.71 to 0.93 (Lincoff et al, NEJM 2023) Benefit appeared early, before substantial weight loss, supporting a mechanism partly independent of weight reduction
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