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It's incredibly difficult to "overdose" on B12 because your body efficiently removes what it doesn't use

This is especially important for people who have difficulty absorbing nutrients through the digestive system

Most vets who use it treat it as one tool among several

Supplementation of vitamin B12 COMPOSITION Cyanocobalamin (Vitamin B12) 1mg/mL ACTIONS Supplementation of Vitamin B12 INDICATIONS Vitamin B12 supplement for the treatment of macrocytic anaemia in horses and dogs DOSAGE AND ADMINISTRATION Administer intramuscularly twice weekly or as directed by a veterinary surgeon

Both figures assume an 8-week run