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2015;10(7): e0133904

Given the preponderance of data that links nuclear IGF-1R to worse outcomes after IGF-1R - directed treatments, inhibiting nuclear translocation of IGF-1R or inhibiting its sequestration in the nucleus could re-sensitize tumor cells to treatment

We observe through a culmination of various studies the remarkable ability for animals to sustain and neutralize extreme inflammation and oxidative stress under the presence of an Nrf2 activator [79,80]